interleukin-17 gene expression and serum levels in acute rejected and non-rejected liver transplant patients
Authors
abstract
background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sectional study were divided into non- acute rejected (non-ar) and acute rejected (ar) patient groups. three blood samples were collected from each patient in days 1, 4 and 7 post liver transplantation. the il-17 mrna levels were evaluated using an in-house real time pcr protocol. il- 17 protein levels were also analyzed in non-ar, ar and also control groups using elisa method. results: the il-17 mrna expression level continuously increased in ar patients in all days of follow-up post liver transplantation. il-17 expression was, however, down regulated after day 4 post-transplant follow-up in non-ar patients. both il-17 mrna expression and protein levels were also significantly increased in ar patients compared with non-ar ones. conclusion: based on these findings, significant increase of il-17 mrna and protein levels in ar patients highlights the important role of il-17 in acute liver rejection.
similar resources
Interleukin-17 Gene Expression and Serum Levels in Acute Rejected and non-Rejected Liver Transplant Patients
Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...
full textInterleukin-17 gene expression and serum levels in acute rejected and non-rejected liver transplant patients.
BACKGROUND Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. OBJECTIVE To evaluate the role of IL-17 in post-liver transplant acute rejection. METHODS Ninety seven adult liver transplant patients who enrolled in this cross se...
full textInterleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma
Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma. Objective: To determine the role of IL-17 in predicting severe asthma. Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (...
full textInterleukin-17 Serum Levels and TLR4 Polymorphisms in Ulcerative Colitis
Background: Inflammatory bowel disease, an autoimmune disease, has two clinical manifestations including Crohn’s disease and ulcerative colitis (UC). IL-17 has been the target of intensive research in autoimmune diseases. The influence of Toll like receptor 4 (TLR-4) gene polymorphisms on IL-17 production has also been revealed in UC patients and tissue inflammation in mice. Objectives: To inve...
full textInvestigation of Interleukin-17 Gene Polymorphisms and Serum Levels in Patients with Basal Cell Carcinoma of the Skin
full text
Serum Levels of Interleukin 17 in Patients with Pemphigus and Healthy Subjects
Introduction: Pemphigus is a relatively rare autoimmune bullous disease involving skin and mucous epithelia. The disease occurs as a result of production of auto-antibodies against inter-cellular epithelia especially cadherin and desmoglein. Interleukin 17 (IL-17) is one of the specific cytokines of T helper. IL-17 plays an important role in delayed type reaction and recruits neutrophils and mo...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of immunologyجلد ۱۱، شماره ۱، صفحات ۲۹-۳۹
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023